Pyare Mohan is a romantic comedy-drama. The movie revolves around two best friends Pyare (Fardeen Khan), who is blind, and Mohan (Vivek Oberoi), who is deaf. The two friends fall in love with two sisters, Preeti (Esha Deol) and Priya (Amrita Rao). Things take a turn when the girls are falsely accused of killing a priest at Bangkok airport and are arrested. When Pyare and Mohan learn about the same, they rush to protect the girls by catching the killer.